GDC products
نویسندگان
چکیده
منابع مشابه
GDC Working Papers
When unemployment arises, a country often imposes an import tariff since it supposedly expands the market share of domestic firms and encourages them to hire more workers. However, such a policy improves the current account and hence appreciates the home currency. Consequently, home products lose competitiveness against foreign products and eventually employment decreases, contrary to the prior...
متن کاملGDC Working Papers
The paper models the policy challenges facing globalizing developing countries. Models from the pure theory of international trade, the small open economy model, growth accounting, the SolowSwan model, the gravity model, models of portfolio diversification and currency crises models are reviewed to distil policy guidelines to promote the globalization of developing countries. The overriding obj...
متن کاملIntermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition.
Combinations of MAP/ERK kinase (MEK) and phosphoinositide 3-kinase (PI3K) inhibitors have shown promise in preclinical cancer models, leading to the initiation of clinical trials cotargeting these two key cancer signaling pathways. GDC-0973, a novel selective MEK inhibitor, and GDC-0941, a class I PI3K inhibitor, are in early stage clinical trials as both single agents and in combination. The d...
متن کاملCYP1A1-Mediated Intramolecular Rearrangement of Aminoazepane in GDC-0339.
GDC-0339 is a novel small molecule pan-Pim kinase inhibitor that was discovered as a potential treatment of multiple myeloma. During the in vitro and in vivo metabolite profiling of GDC-0339, a metabolite was detected that had the same elemental composition as the parent but was distinct with respect to its chromatographic separation and mass spectrometric fragmentation pattern. High resolution...
متن کاملNovel Mechanism of Decyanation of GDC-0425 by Cytochrome P450.
GDC-0425 [5-((1-ethylpiperidin-4-yl)oxy)-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile] is an orally bioavailable small-molecule inhibitor of checkpoint kinase 1 that was investigated as a novel cotherapy to potentiate chemotherapeutic drugs, such as gemcitabine. In a radiolabeled absorption, distribution, metabolism, and excretion study in Sprague-Dawley rats, trace-level but long-lived 14...
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ژورنال
عنوان ژورنال: British Dental Journal
سال: 2009
ISSN: 0007-0610,1476-5373
DOI: 10.1038/sj.bdj.2009.261